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Hemoglobin solutions have potential as temporary red cell substitutes. Their efficacy has been demonstrated by their ability to maintain life-supporting levels of O2 consumption and CO2 production in animals virtually free of red cells. They do not exhibit major toxic effects, but transient alterations in renal function remain a concern. Cardiac output does not increase in the face of acute anemia associated with isovolemic exchange transfusion with hemoglobin solution. However, cardiac reserve does not diminish significantly after infusion of hemoglobin solution. Alterations in production techniques may lead to a polymerized hemoglobin solution that has a hemoglobin concentration and P50 close to fresh whole blood. Though this development is encouraging, it is clear that no perfect red cell substitute currently is available.
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G S Moss
March 1995,
Transfusion science,
A L Rosen, and
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H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
January 1995,
International anesthesiology clinics,
A L Rosen, and
S A Gould, and
L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
February 1999,
Annales francaises d'anesthesie et de reanimation,
A L Rosen, and
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L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
August 2000,
Critical care medicine,
A L Rosen, and
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L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
January 1987,
Biomaterials, artificial cells, and artificial organs,
A L Rosen, and
S A Gould, and
L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
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January 2000,
Journal of investigative surgery : the official journal of the Academy of Surgical Research,
A L Rosen, and
S A Gould, and
L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
January 1996,
Biotechnology progress,
A L Rosen, and
S A Gould, and
L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
September 2004,
Artificial organs,
A L Rosen, and
S A Gould, and
L R Sehgal, and
H L Sehgal, and
C L Rice, and
D Rushing, and
G S Moss
December 1986,
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna,
A L Rosen, and
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C L Rice, and
D Rushing, and
G S Moss
January 1992,
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology,
