-transparent.png){kind=logo}
Prothrombin (factor II) was assayed in congenital or acquired prothrombin deficiencies and abnormalities using Taipan viper (Oxyuranus scutellatus) venom as activating agent and adsorbed normal plasma or a chromogenic compound (Chromozym-Th) as substrates. Prothrombin was found to be low, as expected in every instance, regardless of the substrate used. In coumarin treated patients the levels observed were similar to the prothrombin time percentile values and definitely lower than the immunological counterparts. Therefore, the Taipan viper venom appears suited for prothrombin assay even during anticoagulant therapy. Since the cost of the chromogenic substrate is about 20 times that of adsorbed normal plasma and since no special information is obtained by it, the use of the chromogenic method is not justified for routine purposes.
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
June 1981,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
October 1977,
Thrombosis research,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
April 1981,
Blut,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
August 1971,
British journal of haematology,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
January 1986,
Toxicon : official journal of the International Society on Toxinology,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
April 1969,
Thrombosis et diathesis haemorrhagica,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
January 1984,
Haemostasis,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
April 2004,
The Journal of biological chemistry,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
July 1955,
The Journal of laboratory and clinical medicine,
A Girolami, and
G Petrassi, and
G Cella, and
P Saltarin
March 1980,
Biochemistry,
