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Since p,p'-DDT-induced myoclonus is ameliorated by serotonin agonists and aggravated by serotonin antagonists, the effect of p,p'-DDT on serotonin metabolism in rat brain was examined. p,p'-DDT (600 mg/kg intragastrically) elevated plasma tryptophan as well as tryptophan and 5-hydroxyindoleacetic acid concentrations in all seven regional areas of the brain assayed. Serotonin levels were elevated only in the midbrain and cerebellum of p,p'-DDT-treated rats. p,p'-DDT increased serotonin turnover in the medulla and midbrain. p,p'-DDT had no effect on the transport of 5-hydroxyindoleacetic acid out of the central nervous system, serotonin uptake and release from nerve terminals, or serotonin receptor binding in the brain. The findings in this study do not support a brain serotonin deficiency hypothesis as the explanation for the response of p,p'-DDT-induced myoclonus to serotonin agonists.
E Chung Hwang, and
M H Van Woert
April 1972,
Journal of neurochemistry,
E Chung Hwang, and
M H Van Woert
April 1994,
European journal of pharmacology,
E Chung Hwang, and
M H Van Woert
February 1987,
Biochimica et biophysica acta,
E Chung Hwang, and
M H Van Woert
January 1973,
Journal of agricultural and food chemistry,
E Chung Hwang, and
M H Van Woert
January 1975,
Journal of agricultural and food chemistry,
E Chung Hwang, and
M H Van Woert
February 2002,
Drug metabolism and disposition: the biological fate of chemicals,
E Chung Hwang, and
M H Van Woert
April 1982,
Toxicology and applied pharmacology,
E Chung Hwang, and
M H Van Woert
September 1976,
Biochemical pharmacology,
E Chung Hwang, and
M H Van Woert
July 1983,
Bulletin of environmental contamination and toxicology,
E Chung Hwang, and
M H Van Woert
January 1994,
Neurotoxicology,
