BIOMAT Database Logo BIOMAT Database Logo

Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions. 1982

M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio

UI MeSH Term Description Entries
D007271 Injections, Intradermal The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer. Intradermal Injections,Injection, Intradermal,Intradermal Injection
D008935 Mitoguazone Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase. Methylglyoxal Bis(guanylhydrazone),MGBG,Methyl-gag,NSC-32946,Methyl gag,Methylgag,NSC 32946,NSC32946
D009952 Ornithine An amino acid produced in the urea cycle by the splitting off of urea from arginine. 2,5-Diaminopentanoic Acid,Ornithine Dihydrochloride, (L)-Isomer,Ornithine Hydrochloride, (D)-Isomer,Ornithine Hydrochloride, (DL)-Isomer,Ornithine Hydrochloride, (L)-Isomer,Ornithine Monoacetate, (L)-Isomer,Ornithine Monohydrobromide, (L)-Isomer,Ornithine Monohydrochloride, (D)-Isomer,Ornithine Monohydrochloride, (DL)-Isomer,Ornithine Phosphate (1:1), (L)-Isomer,Ornithine Sulfate (1:1), (L)-Isomer,Ornithine, (D)-Isomer,Ornithine, (DL)-Isomer,Ornithine, (L)-Isomer,2,5 Diaminopentanoic Acid
D011073 Polyamines Amine compounds that consist of carbon chains or rings containing two or more primary amino groups. Polyamine
D011565 Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D011700 Putrescine A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. 1,4-Butanediamine,1,4-Diaminobutane,Tetramethylenediamine,1,4 Butanediamine,1,4 Diaminobutane
D002262 Carboxy-Lyases Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1. Carboxy-Lyase,Decarboxylase,Decarboxylases,Carboxy Lyase,Carboxy Lyases
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006146 Guanidines A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.
May 1981, Biochimica et biophysica acta,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Alterations in bone marrow and blood mononuclear cell polyamine and methylglyoxal bis(guanylhydrazone) levels: phase I evaluation of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) treatment of human hematological malignancies.
March 1988, Cancer research,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Potentiation of methylglyoxal-bis-guanylhydrazone by alpha-difluoromethylornithine in rat prostate cancer.
March 1984, Cancer,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Sequential inhibition of polyamine synthesis. A phase I trial of DFMO (alpha-difluoromethylornithine) and methyl-GAG [methylglyoxal-bis(guanylhydrazone)].
January 1983, Cancer chemotherapy and pharmacology,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Effects of DL-alpha-difluoromethylornithine, 4-deoxypyridoxine and methylglyoxal bis(guanylhydrazone) on allograft prolongation.
January 1991, Life sciences,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
February 1985, Cancer research,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Methylglyoxal bis(guanylhydrazone) analogs. VI. Methylglyoxal bis(guanylhydrazone) pamoate.
August 1968, Journal of pharmaceutical sciences,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Some properties of the polyamine deprivation-inducible uptake system for methylglyoxal bis(guanylhydrazone) in tumor cells.
January 1981, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Methylglyoxal bis(guanylhydrazone) elimination of polyamine effects on protein synthesis.
October 1985, Archives of biochemistry and biophysics,
M Kousa, and K Käpyaho, and J Lauharanta, and K Linnamaa, and J Jänne, and K Mustakallio
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
October 1984, Cancer research,
Copied contents to your clipboard!