Biomaterial Database

[Hepatitis B antigen (HBSAG) in hospitalized children]. 1977

C Meier, and M Frey-Wettstein

Blood samples of 1940 hospitalized children aged 0--18 years were investigated for presence of HBs-Ag by counter-electrophoresis, haemagglutination and radioimmunoassay, HBs-Ag was found in 1.34% of all patients, being distributed evenly amongst boys and girls. The incidence was 1.7% in patients from a large University children's hospital and 0.6% in patients from a group of regional hospitals. Of 26 samples positive by radioimmunoassay, 1 only was found positive by insensitive counter-electrophoresis. In addition to diseases known to be correlated with HBs-antigenaemia in adults, there was an accumulation of inborn deformities as well as perinatal and neurologic disorders in HBs-Ag positive children. Vertical transmission of hepatitis-B virus from pregnant or nursing mothers to their children could not be found. The incidence of HBs-antigenaemia increases little with age, thus infection in early childhood appears probable at least in a part of the cases.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297	Male		Males
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011863	Radioimmunoassay	Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.	Radioimmunoassays
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002673	Child, Hospitalized	Child hospitalized for short term care.	Hospitalized Child,Children, Hospitalized,Hospitalized Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003378	Counterimmunoelectrophoresis	Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.	Electrosyneresis,Immunoelectroosmophoresis,Immunoelectrophoresis, Countercurrent,Immunoelectrophoresis, Crossover,Countercurrent Immunoelectrophoresis,Crossover Immunoelectrophoresis
D005260	Female		Females