Biomaterial Database

Meaning of the cardiac output-blood volume relationship in essential hypertension. 1982

N P Chau, and T G Coleman, and G M London, and M E Safar

This study interprets the cardiac output-blood volume relationship in essential hypertension. Previous reports indicated that the chronic volume-flow slope (i.e., the regression coefficient alpha, cardiac output = alpha blood volume + beta, obtained from steady-state volume and flow) and the transient volume-flow slope observed during a dextran infusion were both steeper in essential hypertensives than in normotensives. By applying the Guyton-Coleman circulatory model to essential hypertension, this reports demonstrates that: 1) several alterations of the circulatory system may theoretically change the steady state of volume and flow and generate a chronic volume-flow relationship. However, only alterations of the kidney function and of the autonomic nervous system may produce a volume-flow curve compatible with the available data. 2) As hypertension develops, vascular resistance and compliance have the greatest influence on the slope of the chronic volume-flow curve. 3) To account for the observed increase of this slope in the transition from normotension to essential hypertension, not only must resistance be increased but also compliance must be reduced in essential hypertension. The same conclusions are drawn from the study of the transient volume-flow relationship observed during the dextran infusion.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297	Male		Males
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D001810	Blood Volume	Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.	Blood Volumes,Volume, Blood,Volumes, Blood
D002302	Cardiac Output	The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).	Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D003911	Dextrans	A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.	Dextran,Dextran 40,Dextran 40000,Dextran 70,Dextran 75,Dextran 80,Dextran B-1355,Dextran B-1355-S,Dextran B1355,Dextran B512,Dextran Derivatives,Dextran M 70,Dextran T 70,Dextran T-40,Dextran T-500,Hemodex,Hyskon,Infukoll,Macrodex,Polyglucin,Promit,Rheodextran,Rheoisodex,Rheomacrodex,Rheopolyglucin,Rondex,Saviosol,Dextran B 1355,Dextran B 1355 S,Dextran T 40,Dextran T 500
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man