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The purpose of this study was to determine the antiviral effect of human leukocyte interferon on Epstein-Barr virus (EBV) viral capsid antigen (VCA) and early antigen (EA) induction in B95-8 and Raji cells. Interferon made at the Institute of Virology, Beijing, and that provided by Dr. Cantell gave unexpected results. Both interferon preparations markedly enhanced spontaneous VCA and EA induction in B95-8 cells and EA induction in Raji cells simultaneously treated with croton oil and n-butyrate. Interferon treatment alone had no effect on EA induction in Raji cells. Thus, the effect of interferon on EA and VCA induction was related to the type of EBV infection, i.e., productive or latent. The enhancing activity of interferon could only be partially inhibited by retinoid 7901. It is suggested that the mechanism for enhancement of EA induction by interferon is different from that of EA induction in Raji cells by croton oil and n-butyrate.
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