Biomaterial Database

Myocardial blood flow during acute isovolumic anemia and treadmill exercise in dogs. 1982

D R Abendschein, and J E Fewell, and C J Carlson, and E Rapaport

We examined whether submaximal treadmill exercise during acute isovolumic anemia altered the distribution of myocardial blood flow and thus caused subendocardial ischemia in unsedated dogs. Myocardial blood flow (determined by the microsphere method) and left ventricular function (indicated by pressures, volumes, and contractile indices) were measured in five dogs at rest and during exercise before and after equal volume exchange of blood and 6% dextran 70, which lowered hematocrit from 36 +/- 4 to 18 +/- 2% (SD). Total myocardial blood flow increased from 175 +/- 65 to 296 +/- 151 ml . min-1 . 100 g-1 (69%) during exercise before anemia and from 329 +/- 61 to 599 +/- 126 (82%) during exercise after anemia. The distribution of blood flow to the left and right ventricles and interventricular septum as well as the subendothelial-to-subepicardial blood flow ratio in these areas did not change during exercise either before or after anemia. Left ventricular function was not impaired during exercise after anemia. We conclude that subendocardial ischemia does not occur when dogs exercise during acute isovolumic anemia.

UI	MeSH Term	Description	Entries
D010496	Pericardium	A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.	Epicardium,Fibrous Pericardium,Parietal Pericardium,Pericardial Cavity,Pericardial Space,Serous Pericardium,Visceral Pericardium,Cavities, Pericardial,Cavity, Pericardial,Pericardial Cavities,Pericardial Spaces,Pericardium, Fibrous,Pericardium, Parietal,Pericardium, Serous,Pericardium, Visceral,Pericardiums, Fibrous,Pericardiums, Serous,Serous Pericardiums,Space, Pericardial,Spaces, Pericardial
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002302	Cardiac Output	The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).	Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D003326	Coronary Circulation	The circulation of blood through the CORONARY VESSELS of the HEART.	Circulation, Coronary
D003911	Dextrans	A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.	Dextran,Dextran 40,Dextran 40000,Dextran 70,Dextran 75,Dextran 80,Dextran B-1355,Dextran B-1355-S,Dextran B1355,Dextran B512,Dextran Derivatives,Dextran M 70,Dextran T 70,Dextran T-40,Dextran T-500,Hemodex,Hyskon,Infukoll,Macrodex,Polyglucin,Promit,Rheodextran,Rheoisodex,Rheomacrodex,Rheopolyglucin,Rondex,Saviosol,Dextran B 1355,Dextran B 1355 S,Dextran T 40,Dextran T 500
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004699	Endocardium	The innermost layer of the heart, comprised of endothelial cells.	Endocardiums
D004911	Erythrocyte Volume	Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.	Red Cell Mass,Erythrocyte Volumes,Mass, Red Cell,Masses, Red Cell,Red Cell Masses,Volume, Erythrocyte,Volumes, Erythrocyte
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D000208	Acute Disease	Disease having a short and relatively severe course.	Acute Diseases,Disease, Acute,Diseases, Acute