BIOMAT Database Logo BIOMAT Database Logo

Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts. 1982

M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost

Determination of myocardial infarct size is important for clinical management of patients with ischemic heart disease and for research on limiting infarct size. Nuclear magnetic resonance (NMR) imaging permits tomographic depiction of the distribution of mobile tissue protons. NMR images have demonstrated high spatial resolution and contrast. To evaluate the potential of this technique in measuring myocardial infarct size, NMR imaging was performed in six canine hearts excised 24 hours after circumflex coronary artery ligation. Before sacrifice, the dogs received i.v. manganous chloride (0.05 mmol/kg). After NMR imaging, the heart were sectioned and the myocardial slices were stained with triphenyl tetrazolium chloride. The pathologically determined infarct size was compared with the infarct size measured by NMR imaging. The correlation was good (regression line slope 1.06; r = 0.94). We conclude that NMR imaging with paramagnetic contrast agents can be used to determine infarct size in excised hearts.

UI MeSH Term Description Entries
D008297 Male Males
D009203 Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). Cardiovascular Stroke,Heart Attack,Myocardial Infarct,Cardiovascular Strokes,Heart Attacks,Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarctions,Myocardial Infarcts,Stroke, Cardiovascular,Strokes, Cardiovascular
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004578 Electron Spin Resonance Spectroscopy A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING. ENDOR,Electron Nuclear Double Resonance,Electron Paramagnetic Resonance,Paramagnetic Resonance,Electron Spin Resonance,Paramagnetic Resonance, Electron,Resonance, Electron Paramagnetic,Resonance, Electron Spin,Resonance, Paramagnetic
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013194 Staining and Labeling The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts. Histological Labeling,Staining,Histological Labelings,Labeling and Staining,Labeling, Histological,Labelings, Histological,Stainings
D014054 Tomography Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane. Tomographies

Related Publications

M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Paramagnetic pyrophosphate. Preliminary studies on magnetic resonance contrast enhancement of acute myocardial infarction.
February 1990, Investigative radiology,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Contrast enhancement in magnetic resonance imaging using intravenous paramagnetic contrast media: a review.
January 2000, Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
In vivo nuclear magnetic resonance imaging of myocardial perfusion using the paramagnetic contrast agent manganese gluconate.
August 1989, Journal of the American College of Cardiology,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Paramagnetic contrast agents in nuclear magnetic resonance medical imaging.
October 1983, Seminars in nuclear medicine,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Serial imaging of canine myocardial infarction by in vivo nuclear magnetic resonance.
April 1986, Journal of the American College of Cardiology,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Microwave tomography for detection/imaging of myocardial infarction. I. Excised canine hearts.
March 2003, Annals of biomedical engineering,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Nuclear magnetic resonance spectroscopy of excised human hearts.
September 1992, British heart journal,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
[Nuclear magnetic resonance imaging of myocardial infarction].
October 1984, Kokyu to junkan. Respiration & circulation,
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
[Diagnosis of myocardial infarction and myocardial viability using contrast-enhanced magnetic resonance imaging].
June 2002, Deutsche medizinische Wochenschrift (1946),
M R Goldman, and T J Brady, and I L Pykett, and C T Burt, and F S Buonanno, and J P Kistler, and J H Newhouse, and W S Hinshaw, and G M Pohost
Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging.
October 2005, Scandinavian cardiovascular journal : SCJ,
Copied contents to your clipboard!