-transparent.png){kind=logo}
A newly synthesized compound, [[3-(1H-tetrazol-5-yl)-phenyl] amino]oxoacetic acid n-butyl ester (MTB) has been demonstrated to be an orally active antiallergic agent. This compound inhibited the 48-hr passive cutaneous anaphylaxis (48-hr PCA) induced by IgE in rats. In guinea pigs, MTB also inhibited the 8-day passive cutaneous anaphylaxis (8-day PCA) and the 8-day passive systemic anaphylaxis induced by IgE. The compound partially inhibited the IgG-mediated 3-hr PCA in rats and guinea pigs, but failed to have any effect on the rabbit IgG-mediated 3-hr PCA in these animals. In the rat, MTB was not an antagonist of histamine or serotonin. The antiallergic effect of MTB was not mediated via any adrenergic mechanisms. MTB significantly inhibited histamine release from rat peritoneal cells induced by rat IgE in vitro.
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
February 1984,
Journal of medicinal chemistry,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
October 1983,
Journal of medicinal chemistry,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
November 1986,
Journal of medicinal chemistry,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
May 2009,
Acta crystallographica. Section E, Structure reports online,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
June 1989,
Japanese journal of pharmacology,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
January 2010,
Bioinorganic chemistry and applications,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
April 1990,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
October 2012,
Acta crystallographica. Section E, Structure reports online,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
April 2012,
Acta crystallographica. Section E, Structure reports online,
M Agata, and
H Goto, and
Y Tsuriya, and
K Tachibana, and
T Kuroda
January 1977,
Journal of medicinal chemistry,
