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To study the possibilities of long-term obsidan treatment of ischaemic heart disease (IHD) patients with high risk of sudden death 865 men aged 35-39 years with IHD were examined twice. After the examination including a 24-hour ECG monitoring and the tread-mill test 175 men were selected with grade 2 and over of ventricular extrasystole without contraindications to prolonged treatment with obsidan. The patients were divided into two groups: the treated group (with obsidan) and a control group without active treatment. The treatment with obsidan began with 40 mg/day, the dose being gradually increased. The daily dose was assessed as adequate for stable decrease of the heart rate by 15-20%. As a result of treatment it was possible to decrease the heart rate by 19.2%, on the average, in the control group it was 2.8%. Systolic and diastolic arterial pressure decreased in the first group by 11%, in the control group it rose by 4%. Improvement in angina pectoris course in the first group rose by 16%, in the other group only by 6%. A certain tendency has been recorded in the group of obsidan treated patients to lowering the number of those with 4-5 grades of ventricular extra-systole.
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