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An established line of mouse fibroblasts (10T1/2 cells) cultured in vitro was used to compare the incidence of oncogenic transformation produced by x rays, the hypoxic cell radiosensitizer misonidazole, and a range of commonly used chemotherapy agents. A 3-day exposure to misonidazole at a concentration obtainable during treatment produced an incidence of transformation similar to that of about 50 rad. When chemotherapy agents were tested at concentrations comparable to those used clinically and matched to produce similar cell killing, the incidence of transformation varied widely: some agents, such as vincristine, did not produce transformation at a level detectable above background, while others, such as cis-platinum, appear to be potent carcinogens and produce transformation at a rate orders of magnitude higher than that achieved with x rays.
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
October 1983,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
January 2000,
Advances in space research : the official journal of the Committee on Space Research (COSPAR),
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
May 1984,
Radiation research,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
March 1991,
Radiation research,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
January 1981,
Archives of otolaryngology (Chicago, Ill. : 1960),
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
January 1986,
Cancer research,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
December 1982,
Annals of the New York Academy of Sciences,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
February 1995,
The British journal of radiology,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
October 1984,
Radiation research,
E J Hall, and
R C Miller, and
R Osmak, and
M Zimmerman
November 1930,
Genetics,
