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Continuous feeding of alpha-naphthylisothiocyanate to young male Sprague-Dawley rats was shown to produce a concentration-dependent increase in the number of hepatic ductular cells and a concentration- and time-dependent elevation of serum and liver gamma-glutamyl transpeptidase and alpha-fetoprotein. In liver, the increased gamma-glutamyltranspeptidase and alpha-fetoprotein were predominantly confined to the proliferative ductular cell population. It is concluded that early stages of intoxication by the noncarcinogen alpha-naphthylisothiocyanate resemble early stages in induction of liver neoplasia by carcinogens that evoke ductular proliferation. Elevation of gamma-glutamyltranspeptidase and alpha-fetoprotein expression by an expanding ductular cell population characterizes both processes. However, the increase is rapidly reversed after alpha-naphthylisothiocyanate is discontinued, in contrast to the persistence that has been reported when acetylaminofluorene was administered.
W L Richards, and
Y Tsukada, and
V R Potter
October 1982,
Toxicology and applied pharmacology,
W L Richards, and
Y Tsukada, and
V R Potter
April 1987,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
W L Richards, and
Y Tsukada, and
V R Potter
January 1967,
Postepy higieny i medycyny doswiadczalnej,
W L Richards, and
Y Tsukada, and
V R Potter
September 1988,
Cancer research,
W L Richards, and
Y Tsukada, and
V R Potter
January 1990,
Annals of the New York Academy of Sciences,
W L Richards, and
Y Tsukada, and
V R Potter
December 1970,
Lancet (London, England),
W L Richards, and
Y Tsukada, and
V R Potter
April 1972,
Deutsche medizinische Wochenschrift (1946),
W L Richards, and
Y Tsukada, and
V R Potter
January 1981,
Methods in enzymology,
W L Richards, and
Y Tsukada, and
V R Potter
January 1975,
Advances in clinical chemistry,
W L Richards, and
Y Tsukada, and
V R Potter
August 1973,
Deutsche medizinische Wochenschrift (1946),
