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A comparative study of rat kidney and carcinoma RA tRNA-methylase activity has been carried out using partially purified enzyme preparations and total E. coli tRNA. Also the nuclease activity of the methylase preparations from kidney and carcinoma was compared. It was established that the methylase activity in carcinoma preparations is higher, whereas the nuclease activity is lower in comparison to the enzyme preparations from liver. No formation of some specific methylated compounds could be established in the case of carcinoma. It was established that the relative contribution of individual methylases to the elevated level of total tRNA-methylase activity in carcinoma is different. Maximal enhancement of activity was established for the methylase forming m5U, whereas the activity of the enzymes, transfering the methyl group to the fifth position of C is practically equal in kidney and carcinoma tissues. Experimental results and theoretical evaluation of the hypotheses suggested to explain the higher methylase activity in tumor tissues allowed to reject some of them.
V A Deev, and
T V Venkstern, and
A A Baev
February 1971,
Proceedings of the National Academy of Sciences of the United States of America,
V A Deev, and
T V Venkstern, and
A A Baev
February 2023,
International journal of molecular sciences,
V A Deev, and
T V Venkstern, and
A A Baev
January 1971,
Federation proceedings,
V A Deev, and
T V Venkstern, and
A A Baev
November 1967,
Molecular pharmacology,
V A Deev, and
T V Venkstern, and
A A Baev
April 1950,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
V A Deev, and
T V Venkstern, and
A A Baev
May 1971,
FEBS letters,
V A Deev, and
T V Venkstern, and
A A Baev
October 1971,
The Biochemical journal,
V A Deev, and
T V Venkstern, and
A A Baev
April 1970,
Investigative ophthalmology,
V A Deev, and
T V Venkstern, and
A A Baev
July 1952,
Cancer research,
V A Deev, and
T V Venkstern, and
A A Baev
July 1971,
FEBS letters,
