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The effects of a porcine gastric fundic mucosal extract (molecular weight less than 10 000) has been compared with the effects of eight candidate gastrointestinal peptides on glucose absorption from the jejunum in a rat model. Bolus injection of the extract produced immediate and marked depression of glucose absorption. None of the candidate peptides tested produced this response, although somatostatin and substance P depressed absorption as a late phenomenon after 30 minutes. We conclude that the effects of the fundic extract are not reproduced by any of these candidate peptides. This strengthens the evidence for a novel gastrointestinal peptide, resident in fundic mucosa, which affects absorption from upper small bowel.
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
October 1988,
Hepato-gastroenterology,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
March 1976,
Endocrinology,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
November 1980,
Endocrinology,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
January 1982,
Cell and tissue research,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
November 1981,
Life sciences,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
November 1976,
Metabolism: clinical and experimental,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
January 1992,
Regulatory peptides,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
February 1978,
Endocrinology,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
June 1983,
Life sciences,
N J Andrews, and
S Rinno-Barmada, and
K Burdett, and
J B Elder
April 1985,
General and comparative endocrinology,
