-transparent.png){kind=logo}
We have developed a monoclonal antibody with HLA-DR5 serologic specificity. The antibody, SFR3-DR5, binds specifically to DR5-positive lymphoblastoid cell lines, and immunoprecipitates alpha- and beta-chains characteristic of DR antigens from them. Cytotoxic activity of the antibody segregates with the DR5-bearing haplotype in a family. The antibody reacted with the cells of 16 of 17 DR5 individuals and was negative on all DR5-negative cells tested. SFR3-DR5 reacted weakly with PWM-activated cells of the single DR5 individual whose B lymphocytes were unreactive with the monoclonal antibody by cytotoxicity. Possible interpretations of these results are discussed.
Related Publications
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
November 1985,
Tissue antigens,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
September 1985,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
August 1993,
Tissue antigens,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
June 1988,
Human immunology,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
September 1989,
Immunology today,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
June 1990,
Journal of immunology (Baltimore, Md. : 1950),
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
January 1984,
Immunogenetics,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
March 1981,
Human immunology,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
July 1986,
Tissue antigens,
S F Radka, and
C Machamer, and
P Cresswell, and
D D Kostyu, and
F E Ward, and
D B Amos
July 2006,
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
