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In order to maintain a colony of rhesus monkeys with IgE-mediated Ascaris asthma, we evaluated the response of four animals to infection with Ascaris suum ova. All four animals developed immediate-type cutaneous reactivity and airway responses. Serum IgE and IgG antibody responses against Ascaris antigen, as quantitated by the ELISA, were seen in all animals. Peripheral blood histamine release after stimulation with Ascaris antigen was positive in all animals. Airway reactivity to aerosol challenge with Ascaris antigen became positive in all animals and has remained positive for 6 months in three of four animals. Both standard and threshold dose airway types of responses were present. Except for transient eosinophilia, the animals remained in good health. The studies demonstrate that infection with A. suum results in rhesus monkeys with IgE-mediated immediate-type reactivity that simulates the naturally occurring model of asthma.
R Patterson, and
K E Harris, and
J J Pruzansky
December 1978,
Journal of applied physiology: respiratory, environmental and exercise physiology,
R Patterson, and
K E Harris, and
J J Pruzansky
August 1977,
The Journal of allergy and clinical immunology,
R Patterson, and
K E Harris, and
J J Pruzansky
November 1976,
Journal of applied physiology,
R Patterson, and
K E Harris, and
J J Pruzansky
January 1993,
International archives of allergy and immunology,
R Patterson, and
K E Harris, and
J J Pruzansky
January 2008,
Journal of pharmacological sciences,
R Patterson, and
K E Harris, and
J J Pruzansky
December 1986,
Veterinary parasitology,
R Patterson, and
K E Harris, and
J J Pruzansky
January 1971,
International archives of allergy and applied immunology,
R Patterson, and
K E Harris, and
J J Pruzansky
December 1976,
Life sciences,
R Patterson, and
K E Harris, and
J J Pruzansky
November 1984,
Veterinary parasitology,
R Patterson, and
K E Harris, and
J J Pruzansky
January 1985,
Natural immunity and cell growth regulation,
