Biomaterial Database

Renal injury by companion kidney during hypothermic pulsatile perfusion. 1978

C B Anderson, and S D Haid, and K A Hruska, and E E Etheredge

To study possible deleterious effects of traumatized kidneys on well harvested ones during hypothermic pulsatile perfusion, paired dog kidneys were monitored on two separate MOX-100 machines connected to pool a common perfusate. First kidneys were optimally harvested and baseline renal vascular resistance (RVR) calculated from pressure divided by flow (mm Hg/ml minute). After 1 hour second kidneys were added and observation was continued for an additional 3 hours. RVR in first kidneys increased immediately and doubled by 3 hours when ischemic traumatized second kidneys were added, 0.70 +/- 0.07 to 1.37 +/- 0.15 (p less than 0.001). No change in RVR was noted when second kidneys were optimally retrieved or if the dogs were heparinized prior to nephrectomy. Histological examination showed no evidence of vascular obstruction in any kidney, but only tubular necrosis in nonheparinized, traumatized second kidneys. Weight gain in optimally removed kidneys was 41%, but only 8% in ischemic kidneys. RVR decreased unexpectedly in ischemic kidneys during 3 hours of perfusion (p less than 0.01). Release of vasoactive substances by damaged kidneys and arteriovenous shunting may explain these findings. Separate perfusion systems seem to be justified when one of two cadaver kidneys is of marginal quality.

UI	MeSH Term	Description	Entries
D007036	Hypothermia, Induced	Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.	Induced Hypothermia,Mild Hypothermia, Induced,Moderate Hypothermia, Induced,Targeted Temperature Management,Therapeutic Hypothermia,Hypothermia, Therapeutic,Induced Mild Hypothermia,Induced Mild Hypothermias,Induced Moderate Hypothermia,Induced Moderate Hypothermias,Mild Hypothermias, Induced,Moderate Hypothermias, Induced,Targeted Temperature Managements
D007511	Ischemia	A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	Ischemias
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007683	Kidney Tubular Necrosis, Acute	Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.	Lower Nephron Nephrosis,Acute Kidney Tubular Necrosis,Lower Nephron Nephroses,Nephron Nephroses, Lower,Nephron Nephrosis, Lower,Nephroses, Lower Nephron,Nephrosis, Lower Nephron
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009392	Nephrectomy	Excision of kidney.	Heminephrectomy,Heminephrectomies,Nephrectomies
D009926	Organ Preservation	The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).	Organ Preservations,Preservation, Organ,Preservations, Organ
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog