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Polymorphonuclear leukocyte chemiluminescence and chemotaxis assays were performed on cells obtained from normal individuals and patients with defined defects in chemotaxis or chemiluminescence. After in-vitro pre-incubation with trimethoprim/sulphamethoxazole, its separate components, clindamycin and cefotaxime, normal cells showed some enhancement in chemotaxis and significant increase in chemiluminescence. There was an even more marked increase in chemotaxis when these antibiotics were incubated with cells from patients with leukocyte chemotaxic defects. When the cells from patients with chemiluminescence defects were pre-incubated with these antibiotics, there was also substantial enhancement in chemiluminescence.
J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
R Lin, and
A Minnefor
April 1994,
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
R Lin, and
A Minnefor
January 1980,
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
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A Minnefor
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
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R Cooper, and
R Singh, and
R Lin, and
A Minnefor
January 1986,
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
R Lin, and
A Minnefor
July 1982,
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
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A Minnefor
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
R Lin, and
A Minnefor
January 1979,
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
R Lin, and
A Minnefor
May 1985,
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J M Oleske, and
A de la Cruz, and
H Ahdieh, and
D Sorvino, and
J La Braico, and
R Cooper, and
R Singh, and
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A Minnefor
April 1982,
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A de la Cruz, and
H Ahdieh, and
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J La Braico, and
R Cooper, and
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R Lin, and
A Minnefor
January 1981,
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