Biomaterial Database

Comparison of the inhibitory effects of nifedipine, nitroglycerin, and nitroprusside sodium on different types of activation in canine coronary arteries, with comparative studies in human coronary arteries. 1983

G Weinheimer, and K Golenhofen, and K Mandrek

The mechanical activity of helical strips from canine coronary arteries was recorded. Vessels from normal hearts and from hearts with a collateral circulation after experimental occlusion were investigated. Two types of activation were studied: (a) activation induced by noradrenaline, 10(-5) M, after blockade of beta-adrenoceptors with propranolol (NA activation) and (b) activation induced by application of tetraethylammonium (TEA), 10(-2) M, after blockade of endogenous prostaglandin synthesis by indomethacin, 2 X 10(-6) M (TEA activation). TEA activation was more sensitive to nifedipine (ED50, 2 X 10(-8) M) than to nitroglycerin (ED50, 10(-7) M) or nitroprusside sodium (ED50, 3 X 10(-7) M). NA activation, on the other hand, was more sensitive to nitroglycerin (ED50, 10(-8) M) or nitroprusside sodium (ED50, 2 X 10(-8) M) than to nifedipine (ED50, 6 X 10(-8) M). In comparative studies with human coronary arteries excised postmortem, spontaneous rhythmic activity was often observed. This phasic activity was, as in TEA activation of canine coronary arteries, more sensitive to fedipine than to nitroglycerin. The differences between human and canine coronary smooth muscle are discussed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D009543	Nifedipine	A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.	Adalat,BAY-a-1040,Bay-1040,Cordipin,Cordipine,Corinfar,Fenigidin,Korinfar,Nifangin,Nifedipine Monohydrochloride,Nifedipine-GTIS,Procardia,Procardia XL,Vascard,BAY a 1040,BAYa1040,Bay 1040,Bay1040,Monohydrochloride, Nifedipine,Nifedipine GTIS
D009599	Nitroprusside	A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.	Nitroferricyanide,Sodium Nitroprusside,Cyanonitrosylferrate,Ketostix,Naniprus,Nipride,Nipruton,Nitriate,Nitropress,Nitroprussiat Fides,Nitroprusside, Disodium Salt,Nitroprusside, Disodium Salt, Dihydrate,Disodium Salt Nitroprusside,Nitroprusside, Sodium
D011453	Prostaglandins	A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.	Prostaglandin,Prostanoid,Prostanoids
D011942	Receptors, Adrenergic, alpha	One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.	Adrenergic alpha-Receptor,Adrenergic alpha-Receptors,Receptors, alpha-Adrenergic,alpha-Adrenergic Receptor,alpha-Adrenergic Receptors,Receptor, Adrenergic, alpha,Adrenergic alpha Receptor,Adrenergic alpha Receptors,Receptor, alpha-Adrenergic,Receptors, alpha Adrenergic,alpha Adrenergic Receptor,alpha Adrenergic Receptors,alpha-Receptor, Adrenergic,alpha-Receptors, Adrenergic
D003331	Coronary Vessels	The veins and arteries of the HEART.	Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D005292	Ferricyanides	Inorganic salts of the hypothetical acid, H3Fe(CN)6.