BIOMAT Database Logo BIOMAT Database Logo

Affinity-purified antigen-specific products produced by T cells share epitopes recognized by heterologous antisera raised against several different antigen-specific products from T cells. 1983

R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel

Heterologous antisera to murine or rat T-cell antigen-binding molecules (T-ABM) were raised in rabbits or sheep. The T-ABM used for immunization were purified by affinity for antigen and did not bear known immunoglobulin isotypes. T-ABM and anti-T-ABM were raised in three separate laboratories. Antisera to T-ABM were exchanged and tested for binding to T-ABM in three separate laboratories. Thus antisera to at least three distinct T-ABM were tested directly for binding to T-ABM or by adsorption of biological activity. Rabbit antisera to murine trinitrophenol (TNP)-specific T-ABM or rat AgB-specific T-ABM bound both murine or rat T-ABM, indicating evolutionary conservation of T-ABM. Similar results were found with sheep antisera to murine T-ABM. In addition, all heterologous anti-T-ABM antisera used bound murine T-ABM specific for TNP, 4-hydroxy-3-nitrophenyl acetate (NP), SRBC, or T-cell membrane proteins with similar structure. Thus, there is a commonality of antigenic determinants between various T-ABM and T-cell membrane homologues which may be T-cell surface receptors for foreign antigen.

UI MeSH Term Description Entries
D007106 Immune Sera Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen. Antisera,Immune Serums,Sera, Immune,Serums, Immune
D007130 Immunoglobulin Idiotypes Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains. Idiotypes, Immunoglobulin,Ig Idiotypes,Idiotype, Ig,Idiotype, Immunoglobulin,Idiotypes, Ig,Ig Idiotype,Immunoglobulin Idiotype
D007518 Isoantibodies Antibodies from an individual that react with ISOANTIGENS of another individual of the same species. Alloantibodies
D008222 Lymphokines Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity. Lymphocyte Mediators,Mediators, Lymphocyte
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009596 Nitrophenols PHENOLS carrying nitro group substituents. Nitrophenol
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D011917 Rats, Inbred Lew An inbred strain of rat that is used in BIOMEDICAL RESEARCH. Rats, Inbred Lewis,Rats, Lew,Inbred Lew Rat,Inbred Lew Rats,Inbred Lewis Rats,Lew Rat,Lew Rat, Inbred,Lew Rats,Lew Rats, Inbred,Lewis Rats, Inbred,Rat, Inbred Lew,Rat, Lew
D011948 Receptors, Antigen, T-Cell Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains. Antigen Receptors, T-Cell,T-Cell Receptors,Receptors, T-Cell Antigen,T-Cell Antigen Receptor,T-Cell Receptor,Antigen Receptor, T-Cell,Antigen Receptors, T Cell,Receptor, T-Cell,Receptor, T-Cell Antigen,Receptors, T Cell Antigen,Receptors, T-Cell,T Cell Antigen Receptor,T Cell Receptor,T Cell Receptors,T-Cell Antigen Receptors

Related Publications

R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
November 2013, Journal of immunology (Baltimore, Md. : 1950),
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Improvement of antisera raised against complex antigen mixtures by the use of heterologous sources of antigen for immunization.
April 1993, Journal of immunological methods,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Characterization of epitopes recognized by hapten-specific CD4+ T cells.
February 1995, Journal of immunology (Baltimore, Md. : 1950),
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines.
June 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
A germ cell-specific nuclear antigen recognized by a monoclonal antibody raised against mouse testicular germ cells.
December 1997, International journal of andrology,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Antigen common to several species, recognized by a rat monoclonal antibody raised against syngeneic rat bladder tumor.
September 1989, International journal of cancer,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Heterologous antisera against specific HL-A antigens.
October 1971, Transplantation,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Recognition of pneumococcal isolates by antisera raised against PspA fragments from different clades.
March 2008, Journal of medical microbiology,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Conformational epitopes specific to carcinoembryonic antigen defined by monoclonal antibodies raised against colon cancer xenografts.
September 1989, Journal of surgical oncology,
R E Cone, and R W Rosenstein, and C A Janeway, and G M Iverson, and J H Murray, and H Cantor, and M Fresno, and J A Mattingly, and M Cramer, and U Krawinkel
Analysis of retroviral pol gene products with antisera raised against fusion proteins produced in Escherichia coli.
August 1986, Journal of virology,
Copied contents to your clipboard!