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Platelet products released by ADP mediated platelet aggregation or by repeated freeze-thawing of platelet-rich-plasma caused inhibition of the dextran sulphate induced activation of prekallikrein, measured amidolytically, in subsequently prepared platelet-poor-plasma. Platelet products did not inhibit the amidolytic activity of contact activated-plasma. Addition of antiserum to platelet factor-4 (PF4) neutralized the inhibitory effect of platelet products towards prekallikrein activation. When platelet released products were fractionated by heparin affinity chromatography, 93% of the PF4 applied and 86% of the inhibitory activity of the starting material was recovered in the high-affinity fraction.
K M Weerasinghe, and
M F Scully, and
V V Kakkar
August 1980,
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K M Weerasinghe, and
M F Scully, and
V V Kakkar
January 1983,
Ukrainskii biokhimicheskii zhurnal (1978),
K M Weerasinghe, and
M F Scully, and
V V Kakkar
January 1972,
The Journal of experimental medicine,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
June 1992,
Inflammation,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
January 1983,
Advances in experimental medicine and biology,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
January 1976,
Ukrains'kyi biokhimichnyi zhurnal,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
October 1987,
Blood,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
October 1992,
Inflammation,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
January 1990,
Medycyna doswiadczalna i mikrobiologia,
K M Weerasinghe, and
M F Scully, and
V V Kakkar
April 1985,
Thrombosis and haemostasis,
