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In a retrospective study of Hirschsprung's disease two monoclonal antineurofilament antibodies were tested immunohistochemically. Biopsy samples of rectum and colon were fixed in formalin and embedded in paraffin. Tissue sections from normal controls and from unaffected colon of patients with Hirschsprung's disease showed partial staining of only some of the axon bundles in the myenteric and in the submucous plexus. In contrast, in all tissue sections from colon affected by Hirschsprung's disease there were heavily stained hyperplastic axon bundles. Sections of colon from patients with various other neurogenic disorders of the colon were studied by the same method; the characteristic Hirschsprung picture was never seen.
P Klück, and
G N van Muijen, and
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D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
March 1984,
Clinical immunology and immunopathology,
P Klück, and
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D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
June 1983,
Journal of the neurological sciences,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
May 1987,
Clinical and experimental immunology,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
January 1983,
Annals of the New York Academy of Sciences,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
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J C Molenaar
October 1998,
Neurology,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
February 1987,
Rinsho byori. The Japanese journal of clinical pathology,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
December 1989,
The Journal of parasitology,
P Klück, and
G N van Muijen, and
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D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
February 1995,
International journal for parasitology,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
January 1987,
Annales de l'Institut Pasteur. Immunology,
P Klück, and
G N van Muijen, and
A W van der Kamp, and
D Tibboel, and
W A van Hoorn, and
S O Warnaar, and
J C Molenaar
August 1987,
Human pathology,
