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This study reports the use of radiolabeled antibody to AFP and CEA for the detection and localization of AFP- or CEA-producing tumors. Thirty-one patients received 131I-labeled anti-AFP or anti-CEA antibodies. Photoscans were taken at 24 and 48 hours after injection of radioantibodies. In three of six patients with CEA-producing tumors, radioimmunodetection with anti-CEA antibody showed positive scans. In AFP-producing tumors, 7 of 15 patients had positive findings on immunoscintigraphy using polyclonal anti-AFP antibody, and two of nine patients had positive findings when monoclonal antibodies were used. Analysis of radioantibody in the blood after injection showed both complex and free antibody with immunoreactivity in the circulation, and smaller complexes were seen to form after administration of monoclonal antibodies.
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March 1988,
Chinese medical journal,
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August 1980,
Cancer research,
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S Nishi
August 1980,
Cancer research,
N Ishii, and
K Nakata, and
T Muro, and
R Furukawa, and
K Kono, and
Y Kusumoto, and
T Munehisa, and
T Koji, and
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S Nishi
March 1980,
Cancer research,
N Ishii, and
K Nakata, and
T Muro, and
R Furukawa, and
K Kono, and
Y Kusumoto, and
T Munehisa, and
T Koji, and
S Nagataki, and
S Nishi
August 1980,
Cancer research,
N Ishii, and
K Nakata, and
T Muro, and
R Furukawa, and
K Kono, and
Y Kusumoto, and
T Munehisa, and
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S Nishi
March 1983,
Gastroenterology,
N Ishii, and
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K Kono, and
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S Nishi
February 1983,
Meditsinskaia radiologiia,
N Ishii, and
K Nakata, and
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R Furukawa, and
K Kono, and
Y Kusumoto, and
T Munehisa, and
T Koji, and
S Nagataki, and
S Nishi
May 1983,
Gastroenterology,
N Ishii, and
K Nakata, and
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R Furukawa, and
K Kono, and
Y Kusumoto, and
T Munehisa, and
T Koji, and
S Nagataki, and
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October 1992,
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N Ishii, and
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June 1985,
Kaku igaku. The Japanese journal of nuclear medicine,
