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The pyrimidine metabolism of Tritrichomonas foetus (KV 1) was studied using whole cells and cell homogenates. Pyrimidines and pyrimidine nucleosides were readily incorporated into nucleic acids. Orotate and aspartate were not incorporated into pyrimidine bases. Enzymes of the pyrimidine salvage pathway (i.e., thymidine and uridine phosphorylases and uridine kinase) were detected in trophozoite homogenates, but the activities of de novo pyrimidine synthesis enzymes (i.e., carbamoylphosphate synthase, aspartate transcarbamoylase, dihydroorotase and dihydroorotate dehydrogenase) were below the level of detection in these same homogenates. The evidence presented supports the proposal that T. foetus is incapable of synthesizing pyrimidines de novo but is capable of salvaging preformed pyrimidines and pyrimidine nucleosides from the growth medium and that enzymes of this parasite's pyrimidine salvage pathway are not organelle-associated.
E L Jarroll, and
D G Lindmark, and
P Paolella
May 1983,
Proceedings of the National Academy of Sciences of the United States of America,
E L Jarroll, and
D G Lindmark, and
P Paolella
February 1984,
Experimental parasitology,
E L Jarroll, and
D G Lindmark, and
P Paolella
November 2006,
The Veterinary clinics of North America. Food animal practice,
E L Jarroll, and
D G Lindmark, and
P Paolella
January 1991,
Molecular and biochemical parasitology,
E L Jarroll, and
D G Lindmark, and
P Paolella
March 2005,
Trends in parasitology,
E L Jarroll, and
D G Lindmark, and
P Paolella
June 2007,
The Veterinary record,
E L Jarroll, and
D G Lindmark, and
P Paolella
August 1998,
Veterinary parasitology,
E L Jarroll, and
D G Lindmark, and
P Paolella
July 1986,
Molecular and biochemical parasitology,
E L Jarroll, and
D G Lindmark, and
P Paolella
March 1994,
Parasitology today (Personal ed.),
E L Jarroll, and
D G Lindmark, and
P Paolella
August 1983,
Molecular and biochemical parasitology,
