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The short- and long-term effects of indomethacin administration were examined in normotensive and ACTH-induced hypertensive conscious sheep. Indomethacin, 1 mg/kg/h for 60 min, caused a transient rise in mean arterial pressure (MAP) and calculated total peripheral resistance (CTPR) and a fall in cardiac output in normotensive sheep. In sheep with ACTH hypertension, these haemodynamic effects were prolonged. Indomethacin infusion at 3 mg/kg/day for 3 days had no observable haemodynamic or metabolic effects. Concomitant infusion of ACTH increased MAP and CTPR. These studies suggest prostaglandins play only a minor role in regulation of blood pressure in normal conscious sheep, but modulate the blood pressure rise in ACTH hypertension in sheep.
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
September 1979,
Annals of internal medicine,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
September 1979,
Annals of internal medicine,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
November 1981,
Thrombosis research,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
February 1981,
The American journal of physiology,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
November 1980,
International journal of cancer,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
April 1983,
Medical hypotheses,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
November 1978,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
May 1979,
Annals of internal medicine,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
December 1972,
Acta physiologica Scandinavica,
R T Mason, and
J P Coghlan, and
D A Denton, and
W F Graham, and
T J Humphery, and
B A Scoggins, and
J A Whitworth
October 1985,
Clinical pharmacology and therapeutics,
