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T-cell clones that grow continuously in tissue culture have become a major tool for studying the properties of T lymphocytes. It is therefore important to know to what extent such clones resemble their normal counterparts. Several reports have appeared recently which demonstrate that long-term T-cell lines may lose the specificity for which they were initially selected and acquire cytotoxic activity to a variety of targets, typical of the activity displayed by natural killer cells. We now report a number of instances in which murine cytotoxic T-cell clones have lost their original specific cytotoxic activity but have acquired strong specific cytotoxic activity for P815 mastocytoma target cells. Loss of the original specificity was usually observed after continuous in vitro cultivation for more than 6 months. We propose that this novel type of cytotoxicity should be called aged killer activity.
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
January 1987,
Annales de l'Institut Pasteur. Immunology,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
January 1997,
Anticancer research,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
August 1996,
International journal of cancer,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
July 1993,
Cancer research,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
September 1981,
Immunopharmacology,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
March 1990,
Cancer letters,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
March 2003,
Neuroscience letters,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
December 1981,
Immunopharmacology,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
January 1983,
Scandinavian journal of immunology,
M M Simon, and
H U Weltzien, and
H J Bühring, and
K Eichmann
September 2004,
Life sciences,
