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In postmortem investigations of patients with dementia of Alzheimer type (AD/SDAT) (n = 14) the brain weight was significantly reduced when compared to controls (n = 16). In four AD/SDAT-brain parts investigated the concentrations of 5-hydroxy-tryptamine and noradrenaline were significantly reduced while 3-methoxy-4-hydroxyphenylglycol was significantly increased. In the caudate nucleus of the AD/SDAT-brains the concentrations of dopamine and homovanillic acid were significantly reduced. The activity of monoamine oxidase B was increased suggesting a proliferation of extra neuronal tissue in the AD/SDAT-brains. The activity of choline acetyl transferase was reduced in the four brain parts investigated, showing a general reduction in the acetylcholine system in the AD/SDAT-brains. The ganglioside concentration was significantly reduced suggesting a reduced density of nerve endings in the demented brains. The AD/SDAT-group was according to rating scales severely demented. Patients with an early onset of the dementia disease were more severely intellectually reduced and had more pronounced biochemical disturbances than those with a late onset of the dementia.
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
April 1990,
Nihon hoigaku zasshi = The Japanese journal of legal medicine,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
June 1992,
Acta neurologica Scandinavica,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
December 1994,
International journal of urology : official journal of the Japanese Urological Association,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
August 1987,
Acta psychiatrica Scandinavica,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
January 1982,
Annals of the New York Academy of Sciences,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
November 1979,
Wisconsin medical journal,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
January 1984,
Psychopharmacology,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
January 1992,
Neuropsychobiology,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
January 1994,
Pharmacopsychiatry,
C G Gottfries, and
R Adolfsson, and
S M Aquilonius, and
A Carlsson, and
S A Eckernäs, and
A Nordberg, and
L Oreland, and
L Svennerholm, and
A Wiberg, and
B Winblad
June 1992,
Neurochemical research,
