-transparent.png){kind=logo}
The interactions between beef tRNATrp with avian myeloblastosis reverse transcriptase have been studied by statistical chemical modifications of phosphate (ethylnitrosourea) and cytidine (dimethyl sulfate) residues, as well as by digestion of complexed tRNA by Cobra venom nuclease and Neurospora crassa endonuclease. Results with nucleases and chemicals show that reverse transcriptase interacts preferentially with the D arm, the anticodon stem and the T psi stem. All these regions are located in the outside of the L-shaped structure of tRNA. This domain of interaction is different to that reported previously in the complex of beef tRNA with the cognate aminoacyl-tRNA synthetase (M. Garret et al.; Eur. J. Biochem. In press). Avian reverse transcriptase destabilizes the region of tRNA where most of the tertiary interactions maintaining the structure of tRNA are located.
M Garret, and
P Romby, and
R Giegé, and
S Litvak
November 1982,
Nucleic acids research,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
September 1980,
Nucleic acids research,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
December 1980,
Archives of biochemistry and biophysics,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
July 1983,
Nucleic acids research,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
July 1985,
Biochemistry international,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
May 1979,
Biochemical and biophysical research communications,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
February 1979,
Journal of virology,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
May 1977,
Proceedings of the National Academy of Sciences of the United States of America,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
April 1976,
Journal of virology,
M Garret, and
P Romby, and
R Giegé, and
S Litvak
July 1975,
The Journal of biological chemistry,
