DDD/DDT pacemakers in the treatment of ventricular tachycardia. 1984

J D Fisher, and S Furman, and S G Kim, and J A Matos, and L E Waspe

The possibility of adapting multimode dual-chamber pacemakers for programmed and burst stimulation was explored in a group of patients with ventricular tachycardia. The potential usefulness and pitfalls of these pacemakers were exemplified in one patient, presented in detail. The implanted DDD pacemaker was programmed to an all-synchronous mode (DDT), permitting programmed ventricular stimulation through synchronization with chest wall stimulation provided by a standard external programmable stimulator. With the ventricular sensing refractory period shortened to 200 ms, both programmed electrical stimulation and burst pacing for termination of induced tachycardias were possible. When medications failed to offer protection against the patient's tachycardias, the ventricular sensing refractory period (and minimum stimulation interval) was increased to 300 ms, thereby permitting burst pacing at up to 200 beats/minute for termination of spontaneous episodes. After many trials to confirm the efficacy of such stimulation, and the lack of muscle potential triggering, the patient was discharged home with the pacemaker in the DDT mode. He was instructed to go to his local emergency room, and was equipped with a portable device to trigger his implanted unit. Subsequently, the patient had successful termination of several spontaneous episodes of ventricular tachycardia in an emergency room. Later, he began to experience palpitations during certain exercises, and it was found that the implanted unit was being triggered by pectoral myopotentials. The unit was therefore reprogrammed to decrease the sensitivity, and the patient was again discharged. The need for careful evaluation and close follow-up is emphasized to maximize the benefits and to minimize the very serious potential risks of this pacing mode.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D010138 Pacemaker, Artificial A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external). Cardiac Pacemaker, Artificial,Artificial Cardiac Pacemaker,Artificial Cardiac Pacemakers,Artificial Pacemaker,Artificial Pacemakers,Cardiac Pacemakers, Artificial,Pacemaker, Artificial Cardiac,Pacemakers, Artificial,Pacemakers, Artificial Cardiac
D010369 Pectoralis Muscles The pectoralis major and pectoralis minor muscles that make up the upper and fore part of the chest in front of the AXILLA. Pectoralis Major,Pectoralis Major Muscle,Pectoralis Minor,Pectoralis Minor Muscle,Pectoral Muscle,Muscle, Pectoral,Muscle, Pectoralis,Muscle, Pectoralis Major,Muscle, Pectoralis Minor,Muscles, Pectoralis Major,Pectoral Muscles,Pectoralis Major Muscles,Pectoralis Majors,Pectoralis Minor Muscles,Pectoralis Minors,Pectoralis Muscle
D005082 Physical Exertion Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included. Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000200 Action Potentials Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli. Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000638 Amiodarone An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. Amiobeta,Amiodarex,Amiodarona,Amiodarone Hydrochloride,Amiohexal,Aratac,Braxan,Corbionax,Cordarex,Cordarone,Kordaron,L-3428,Ortacrone,Rytmarone,SKF 33134-A,Tachydaron,Trangorex,Hydrochloride, Amiodarone,L 3428,L3428,SKF 33134 A,SKF 33134A

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