Biomaterial Database

Platelet factor 4 and beta thromboglobulin in Moya-Moya disease. 1984

M M Albala, and P H Levine

Increased concentrations of PF4 and beta TG were found in two patients with Moya-Moya disease. Although the pathogenesis of these abnormalities is unknown, the increased concentration of these proteins may result from platelet activation in the abnormal vascular network, leading to platelet aggregation and secretion of these two platelet-derived proteins, or alternatively, the increased concentration of these proteins may be the result of platelet aggregation due to a defect in endothelial prostaglandin production.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009072	Moyamoya Disease	A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.	Cerebrovascular Moyamoya Disease,Progressive Intracranial Occlusive Arteropathy (Moyamoya),Moya-Moya Disease,Moyamoya Disease, Classic,Moyamoya Disease, Primary,Moyamoya Disease, Secondary,Moyamoya Syndrome,Classic Moyamoya Disease,Disease, Classic Moyamoya,Disease, Moya-Moya,Disease, Primary Moyamoya,Moya Moya Disease,Moyamoya Diseases, Primary,Primary Moyamoya Disease,Primary Moyamoya Diseases,Secondary Moyamoya Disease
D010974	Platelet Aggregation	The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.	Aggregation, Platelet
D010978	Platelet Factor 4	A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.	Antiheparin Factor,CXCL4 Chemokine,Chemokine CXCL4,Heparin Neutralizing Protein,PF4 (Platelet Factor 4),gamma-Thromboglobulin,CXCL4, Chemokine,Chemokine, CXCL4,gamma Thromboglobulin
D011859	Radiography	Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film).	Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001157	Arterial Occlusive Diseases	Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.	Arterial Obstructive Diseases,Arterial Occlusion,Arterial Obstructive Disease,Arterial Occlusions,Arterial Occlusive Disease,Disease, Arterial Obstructive,Disease, Arterial Occlusive,Obstructive Disease, Arterial,Occlusion, Arterial,Occlusive Disease, Arterial
D001609	Beta-Globulins	Serum proteins with an electrophoretic mobility that falls between ALPHA-GLOBULINS and GAMMA-GLOBULINS.	Beta(1)CA Globulin,Beta-Globulin,Beta Globulin,Beta Globulins

Related Publications

M M Albala, and P H Levine

[Platelet factor 4 and beta-thromboglobulin].

June 1987, Rinsho byori. The Japanese journal of clinical pathology,

M M Albala, and P H Levine

[Beta-thromboglobulin and platelet factor 4. A review].

January 1983, Sangre,

M M Albala, and P H Levine

Amniotic fluid platelet factor 4 and beta-thromboglobulin.

January 1993, Fetal diagnosis and therapy,

M M Albala, and P H Levine

Plasma beta-thromboglobulin and platelet factor 4 in renal insufficiency.

January 1980, Thrombosis research,

M M Albala, and P H Levine

Plasma beta-thromboglobulin and platelet factor 4 in renal failure.

January 1981, Thrombosis research,

M M Albala, and P H Levine

Beta-thromboglobulin and platelet factor 4 in juvenile myocardial infarction.

January 2007, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis,

M M Albala, and P H Levine

[Plasma beta-thromboglobulin and platelet factor 4 in essential hypertension].

December 1988, Zhonghua xin xue guan bing za zhi,

M M Albala, and P H Levine

Fibrinopeptide A, platelet factor 4, and beta-thromboglobulin levels in coronary heart disease.

September 1982, Blood,

M M Albala, and P H Levine

beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) in obstetrical cases.

January 1985, Acta obstetricia et gynecologica Scandinavica,

M M Albala, and P H Levine

Platelet factor 4 and beta-thromboglobulin in inflammatory bowel disease and giant cell arteritis.

March 2000, European journal of clinical investigation,