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Douglas and Rubin suggested that "the role of acetylcholine as a transmitter at the adrenal medulla is to cause some brief change in medullary cells which allows Ca ions to penetrate them and trigger the catecholamine ejection process". The Ca2+-channel blocking agents, verapamil, nifedipine and nitrendipine, have been used widely to investigate the properties of slow Ca2+ channels in a variety of tissues, including the adrenomedullary chromaffin cell. Recently, small modifications to the nifedipine molecule produced a derivative, BAY-K-8644 (methyl-1,4-dihydro-2, 6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylate), that in contrast to the Ca2+-channel blocking agents, stimulated cardiac and vascular smooth muscle contractility. We have tested whether this compound behaves as a Ca2+-channel activator at the chromaffin cell membrane as shown by Schramm et al. in smooth muscle cells. The experiments described here strongly suggest that it does so.
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
September 1988,
Molecular pharmacology,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
April 1985,
Proceedings of the National Academy of Sciences of the United States of America,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
October 1985,
Archives internationales de pharmacodynamie et de therapie,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
December 1989,
The Journal of membrane biology,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
November 1995,
The Journal of pharmacology and experimental therapeutics,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
September 1985,
Journal of neurochemistry,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
January 1989,
Biochemical and biophysical research communications,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
August 1985,
European journal of pharmacology,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
February 1989,
European journal of pharmacology,
A G García, and
F Sala, and
J A Reig, and
S Viniegra, and
J Frías, and
R Fontériz, and
L Gandía
April 1984,
Journal of neurochemistry,
