Biomaterial Database

Studies of myelin proteins in multiple sclerosis brain tissue. 1984

J L Trotter, and C L Wegescheide, and W F Garvey, and W W Tourtellotte

Using radioimmunoassays (RIA) for the myelin specific proteins, myelin proteolipid protein (PLP) and myelin basic protein (MBP) and an enzyme assay for the activity of the myelin marker enzyme 2'3' cyclic-3' phosphohydrolase (CNPase), we have studied plaque, periplaque and normal appearing white matter (NAWM) tissue. We found that all three mylein proteins are decreased in all regions, including NAWM, of MS brain, with a decreasing gradient from NAWM to perregion. Surprisingly, when the ratios of the proteins were calculated, MBP activity, although decreased was found to be relatively preserved.

UI	MeSH Term	Description	Entries
D009103	Multiple Sclerosis	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)	MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009185	Myelin Proteins	MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.	Myelin Protein,Protein, Myelin,Proteins, Myelin
D010727	Phosphoric Diester Hydrolases	A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.	Phosphodiesterase,Phosphodiesterases,Hydrolases, Phosphoric Diester
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D001923	Brain Chemistry	Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.	Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D004676	Myelin Basic Protein	An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.	Golli-MBP1 Protein,Golli-MBP2 Protein,HOG5 Protein,HOG7 Protein,MBP1 Protein,MBP2 Protein,MBP3 Protein,MBP4 Protein,Myelin Basic Protein, 17.2 kDa Isoform,Myelin Basic Protein, 18.5 kDa Isoform,Myelin Basic Protein, 20.2 kDa Isoform,Myelin Basic Protein, 21.5 kDa Isoform,Myelin Basic Protein, Isoform 1,Myelin Basic Protein, Isoform 2,Myelin Basic Protein, Isoform 3,Myelin Basic Protein, Isoform 4,Myelin Basic Protein, Isoform 5,Myelin Basic Protein, Isoform 6,Myelin Basic Protein, Isoform 7,Golli MBP1 Protein,Golli MBP2 Protein
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015087	2',3'-Cyclic-Nucleotide Phosphodiesterases	Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.	2',3'-Cyclic Nucleotide Phosphodiesterase,2',3'-Cyclic Nucleotide Phosphodiesterases,2,3-Cyclic Nucleotide Phosphodiesterase,2,3-Cyclic Nucleotide Phosphodiesterases,CNPase,2',3' Cyclic Nucleotide Phosphodiesterase,2',3' Cyclic Nucleotide Phosphodiesterases,2,3 Cyclic Nucleotide Phosphodiesterase,2,3 Cyclic Nucleotide Phosphodiesterases,Nucleotide Phosphodiesterase, 2',3'-Cyclic,Nucleotide Phosphodiesterase, 2,3-Cyclic,Nucleotide Phosphodiesterases, 2',3'-Cyclic,Nucleotide Phosphodiesterases, 2,3-Cyclic,Phosphodiesterase, 2',3'-Cyclic Nucleotide,Phosphodiesterase, 2,3-Cyclic Nucleotide,Phosphodiesterases, 2',3'-Cyclic Nucleotide,Phosphodiesterases, 2',3'-Cyclic-Nucleotide,Phosphodiesterases, 2,3-Cyclic Nucleotide
D018991	Myelin Proteolipid Protein	A myelin protein that is the major component of the organic solvent extractable lipoprotein complexes of whole brain. It has been the subject of much study because of its unusual physical properties. It remains soluble in chloroform even after essentially all of its bound lipids have been removed. (From Siegel et al., Basic Neurochemistry, 4th ed, p122)	Proteolipid Protein, Myelin,Folch-Lees Protein,Folch-PI Proteolipid Protein,Myelin PLP,Folch Lees Protein,Folch PI Proteolipid Protein,PLP, Myelin,Protein, Folch-Lees,Protein, Folch-PI Proteolipid,Protein, Myelin Proteolipid,Proteolipid Protein, Folch-PI