-transparent.png){kind=logo}
A patient with T-cell prolymphocytic leukemia (T-PLL) is described. The malignant T-cells from the patient were predominantly Leu-2-positive, indicating a suppressor phenotype. The cells were then tested to determine their functional capabilities. The patient's Leu-2-positive cells initially suppressed B-cell proliferation, as predicted by their phenotype but later functioned as T helper cells in the pokeweed mitogen system without a change in phenotype. The cells also responded inadequately to alloantigen and mitogen despite addition of exogenous T-cell growth factor (TCGF). Leu-2-positive prolymphocytes from the spleen of the patient were constitutive producers of TCGF. Surface phenotype using monoclonal antibody was inadequate to predict T-cell function of the cells from this patient with T-PLL. In addition, these data suggest there may be functional subpopulations within the OKT8+ phenotype. Constitutive TCGF production by malignant post-thymic T-cells may represent a mechanism by which these cells sustain their own growth.
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
August 2006,
Leukemia & lymphoma,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
January 1989,
Anticancer research,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
March 2004,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
April 1987,
Blut,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
January 2012,
Hematology. American Society of Hematology. Education Program,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
August 1981,
The Journal of experimental medicine,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
July 2019,
Blood,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
January 2013,
Proceedings (Baylor University. Medical Center),
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
April 2017,
Hematology/oncology clinics of North America,
K W Zamkoff, and
B J Poiesz, and
F W Ruscetti, and
J L Moore, and
F R Davey, and
A T Planas, and
H Lamberson
January 1998,
Cancer control : journal of the Moffitt Cancer Center,
