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Substance P-like immunoreactivity (SPLIR) has been found in fibres and the surroundings of ganglion cells and in a new cell type of rat adrenal medulla, using the indirect immunohistochemical method. These SPLIR-cells are characterized by their localization in the connective tissue in close vicinity of vessels and by acidophilic staining in HE-procedure. Relationships are discussed between the localization of substance P in the adrenal medulla and possible interactions with catecholamines with respect to stress.
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