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24 hours after administration of hydroxythiamine, the vitamin B1 antimetabolite, the rat liver pools of orotic acid, UDP-glucose and ATP show a decrease. The cellular energy charge calculated from the adenylic nucleotide concentrations also appears to be significantly diminished. The de novo pyrimidine synthesis lowers under these conditions, while the rates of formation and destruction of essential UDP-sugars remain unaffected. The nucleic acid content is at the control level. A comparison of specific activities of UTP and RNA allows one to conclude that the previously observed decrease in [14C]orotate incorporation into RNA under the action of hydroxythiamine reflects the inhibition of RNA synthesis.
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
April 1970,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
January 1955,
Bollettino della Societa italiana di biologia sperimentale,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
January 1991,
Kosmicheskaia biologiia i aviakosmicheskaia meditsina,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
January 1978,
Voprosy pitaniia,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
March 1970,
Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
January 2008,
Ukrains'kyi biokhimichnyi zhurnal (1999 ),
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
January 1989,
Voprosy pitaniia,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
December 1944,
The Indian medical gazette,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
January 1979,
Cellular immunology,
A M Khokha, and
B P Fustochenko, and
Iu M Ostrovskiĭ
February 1966,
Naika hokan. Japanese archives of internal medicine,
