BIOMAT Database Logo BIOMAT Database Logo

Treatment of malignant germ cell tumors of the ovary with cisplatin, vinblastine, and bleomycin (PVB). 1984

R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder

Seven patients with germ cell tumors of the ovary were treated with four cycles of cisplatin, vinblastine, and bleomycin. Six patients were without evidence of disease 17+ to 37+ months after completion of the remission-induction chemotherapy, and one patient relapsed after 9 months. Substantial toxicity of the cisplatin, vinblastine, and bleomycin regimen was noted. Despite the high response rate suggested in this small series, the optimal chemotherapeutic treatment for this disease has yet to be determined.

UI MeSH Term Description Entries
D009325 Nausea An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
D009373 Neoplasms, Germ Cell and Embryonal Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS. Germ Cell Cancer,Germ Cell Tumor,Neoplasms, Embryonal and Mixed,Cancer, Embryonal,Cancer, Embryonal and Mixed,Embryonal Neoplasms,Germ Cell Neoplasms,Germ Cell and Embryonal Neoplasms,Germ Cell and Embryonic Neoplasms,Neoplasms, Embryonal,Neoplasms, Germ Cell,Neoplasms, Germ Cell and Embryonic,Cancer, Germ Cell,Cancers, Embryonal,Cancers, Germ Cell,Embryonal Cancer,Embryonal Cancers,Embryonal Neoplasm,Germ Cell Cancers,Germ Cell Tumors,Neoplasm, Embryonal,Tumor, Germ Cell,Tumors, Germ Cell
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D010292 Paresthesia Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence of stimulation. Dysesthesia,Formication,Paresthesia, Distal,Paresthesia, Painful,Distal Paresthesia,Distal Paresthesias,Dysesthesias,Formications,Painful Paresthesia,Painful Paresthesias,Paresthesias,Paresthesias, Distal,Paresthesias, Painful
D001761 Bleomycin A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. BLEO-cell,Blanoxan,Blenoxane,Bleolem,Bleomicina,Bleomycin A(2),Bleomycin A2,Bleomycin B(2),Bleomycin B2,Bleomycin Sulfate,Bleomycins,Bleomycinum Mack,Bléomycine Bellon,BLEO cell,BLEOcell,Bellon, Bléomycine,Mack, Bleomycinum,Sulfate, Bleomycin
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006402 Hematologic Diseases Disorders of the blood and blood forming tissues. Blood Diseases,Hematological Diseases,Blood Disease,Disease, Blood,Disease, Hematologic,Disease, Hematological,Diseases, Blood,Diseases, Hematologic,Diseases, Hematological,Hematologic Disease,Hematological Disease

Related Publications

R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Combination cisplatin, vinblastine, and bleomycin chemotherapy (PVB) for malignant germ-cell tumors of the ovary.
October 1983, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Vinblastine, bleomycin, and cisplatin in malignant germ cell tumors of the ovary.
September 1985, Cancer,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Treatment of malignant nondysgerminomatous germ cell tumors of the ovary with vinblastine, bleomycin, and cisplatin.
May 1986, Cancer,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin.
April 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Treatment of recurrent and persistent germ cell tumors with cisplatin, vinblastine, and bleomycin.
January 1982, Obstetrics and gynecology,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide.
June 1987, The New England journal of medicine,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Long-term survival after vinblastine, bleomycin, and cisplatin treatment in patients with germ cell tumors of the ovary: an update.
November 1987, Gynecologic oncology,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Cisplatin, vinblastine, and bleomycin versus vinblastine, cisplatin, and etoposide in the treatment of advanced germ cell tumors of the testis.
June 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
[Cisplatin, vinblastine and bleomycin (PVB) combination chemotherapy in the treatment of intracranial malignant germ cell tumors--a preliminary report of a phase II study--The Japanese Intracranial Germ Cell Tumor Study Group].
September 1986, Gan no rinsho. Japan journal of cancer clinics,
R Vriesendorp, and J G Aalders, and D T Sleijfer, and P H Willemse, and J Bouma, and N H Mulder
Germ cell malignancies of the ovary: treatment with vinblastine, actinomycin D, bleomycin and cisplatin containing chemotherapy combinations.
September 1982, Cancer,
Copied contents to your clipboard!