The interferons are a group of proteins that have inspired a new era of investigation into biological modification. The interferons are now divided into subgroups characterized by chemical means and correspond to different biological responses which can be observed in terms of the inducer used, and the timing of the response. Identified originally as antiviral agents when homologous cell systems were treated prior to infection, new studies have extended these observations to place the interferons in a central role as a strong force in the regulation of immunologic responses. A marriage of interferonology and cell immunology is enlarging both our understanding of the action of these proteins and our ability to follow the course of an illness and eventually to control its outcome . Genetic engineering has provided a way to process quantities of interferon and provided the molecular sequence of all three classes of IFN including a model of the active site for IFN-alpha. The offshot of the technology developed to study the intracellular processes after interferon treatment have already led to increased sensitivity to detect virally treated diseases. Both the variety of the interferon inducers and the scope of parasites in which it can exert its influence provide a frontier of biological investigation which has at the root of its nature the very secret of life. In addition to cellular phenomena, the positive effects on tumor-bearing organisms and the ill effects on infant animals highlight the potential power of the interferons.