-transparent.png){kind=logo}
Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors.
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
January 1987,
Experimental brain research,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
July 1993,
Brain research,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
January 1992,
Experimental brain research,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
January 1999,
Folia histochemica et cytobiologica,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
June 1992,
Behavioural brain research,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
July 1984,
Brain research,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
June 1992,
Behavioural brain research,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
April 1996,
The European journal of neuroscience,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
January 1991,
The European journal of neuroscience,
S A Greenfield, and
I W Chubb, and
R A Grünewald, and
Z Henderson, and
J May, and
S Portnoy, and
J Weston, and
M C Wright
January 1986,
Neuroscience letters,
