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Planned exposures of rodents to diesel exhaust required development of an exhaust generation and delivery system flexible enough to accommodate varied experimental designs. The features of the exposure system built to meet these needs are summarized. Essential aspects including both the exhaust dilution and delivery system and the computer monitoring and control functions are described. During the first 29 weeks of a study with target particle concentrations of 350, 3500, and 7000 micrograms/m3, the achieved values were 310, 3360, and 6830 micrograms/m3 with coefficients of variation of 23, 10, and 9%, respectively. The system has now operated reliably for more than 24 months.
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
May 2018,
Environment international,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
December 2009,
Toxicology letters,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
July 2012,
Allergy, asthma & immunology research,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
January 1998,
Epidemiology (Cambridge, Mass.),
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
June 2004,
The Annals of occupational hygiene,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
October 1999,
International journal of andrology,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
August 2017,
Toxicological sciences : an official journal of the Society of Toxicology,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
January 1989,
Experimental pathology,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
March 1990,
European journal of epidemiology,
B V Mokler, and
F A Archibeque, and
R L Beethe, and
C P Kelly, and
J A Lopez, and
J L Mauderly, and
D L Stafford
February 1990,
The Western journal of medicine,
