-transparent.png){kind=logo}
Significant and often substantial enhancement of the antitumor properties of several individual phleomycins , by co- administration via intraperitoneal injection of a number of purine analogues, is demonstrated in rats and mice having three diverse tumors. It is evident that the dose levels of both the phleomycin and the amplifier are very significant and that optimal levels vary widely with the actual agents used. Constant serum levels of amplifier can be maintained for several days by administration via silastic-pellet implantation rather than injection, and this route of administration is an effective alternative for amplifiers of low solubility.
Related Publications
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
June 1985,
Cancer research,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
November 1998,
Bioorganic & medicinal chemistry letters,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
December 2000,
Journal of medicinal chemistry,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
May 2006,
Bioorganic & medicinal chemistry,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
December 2003,
Bioorganic & medicinal chemistry,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
May 1980,
Journal of medicinal chemistry,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
May 1990,
Journal of medicinal chemistry,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
January 1992,
Yao xue xue bao = Acta pharmaceutica Sinica,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
May 1993,
Journal of medicinal chemistry,
T E Allen, and
D J Brown, and
W B Cowden, and
G W Grigg, and
N K Hart, and
J A Lamberton, and
A Lane
September 1999,
Bioorganic & medicinal chemistry,
