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The effect of histamine type 2 (H2) receptor antagonists, cimetidine and ranitidine, on the induction and expression of hapten-specific suppressor T cells was studied. The activity of DNBSO3 -induced suppressor cells was evaluated after adoptive transfer to naive syngeneic recipients. Treatment with cimetidine or ranitidine markedly inhibited suppressor T cell activity in a dose-related manner and enhanced the contact sensitivity response to DNFB. Both H2 antagonists were effective in inhibiting the expression and, to a lesser extent, the induction of suppressor T cells. In contrast, norburimamide , a non-H2 antagonist structurally related to cimetidine, was inactive. The relevance of these findings to the clinical observation of cimetidine-induced reversal of acquired tolerance to dinitrochlorobenzene in anergic patients is discussed.
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
July 1984,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
June 1991,
The Nursing clinics of North America,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
July 1988,
Bailliere's clinical gastroenterology,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
December 1974,
American family physician,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
January 1978,
Advances in internal medicine,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
June 1976,
Acta hepato-gastroenterologica,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
April 1992,
European journal of pharmacology,
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
October 1982,
Lancet (London, England),
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
November 1987,
Lancet (London, England),
D E Griswold, and
S Alessi, and
A M Badger, and
G Poste, and
N Hanna
July 1987,
Lancet (London, England),
