-transparent.png){kind=logo}
As opposed to normal human skin where HLA-DR expression is restricted to the Langerhans cell (LC) population, HLA-DR, but not HLA-DS antigens can be readily detected on keratinocytes (KC) in certain disease states, i.e., cutaneous T cell lymphoma (CTCL), graft-vs-host disease (GVHD), and lichen planus (LP). To clarify the cellular origin of KC-bound HLA-DR antigens, we used a monoclonal antibody directed against determinants solely expressed on the cytoplasmic HLA-DR gamma chain (VIC-Y1) and observed that, by immunofluorescence, KC displaying HLA-DR alpha/beta complexes on their surface uniformly displayed cytoplasmic VIC-Y1 reactivity. In view of the crucial role of the gamma chain for HLA-DR biosynthesis, we conclude that HLA-DR antigens on KC are actively synthesized by these cells.
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
April 1986,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
January 1985,
Acta dermato-venereologica,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
July 1984,
Clinical and experimental immunology,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
November 1986,
The Journal of investigative dermatology,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
June 1983,
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
February 1984,
Scandinavian journal of immunology,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
January 1987,
The British journal of dermatology,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
June 1983,
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
May 1980,
The New England journal of medicine,
B Volc-Platzer, and
O Majdic, and
W Knapp, and
K Wolff, and
W Hinterberger, and
K Lechner, and
G Stingl
August 1984,
The Journal of investigative dermatology,
