Biomaterial Database

Irritation and staining by dithranol (anthralin) and related compounds. V. Short-contact and tape-stripping experiments with dithranol and butantrone. 1984

A M Göransson, and P J Kolari, and K K Mustakallio

Dithranol (D) and butantrone (BD) were compared as regards irritation and staining in conditions resembling short-contact therapy. Nine psoriatics were tested with 0.5% D and 0.66% BD using exposures of 20 min and 3 h. Partial removal of the horny layer by 15 tape strippings before and after the exposure resembled the impaired barrier of lesions and posttreatment washing, respectively. Development of erythema and staining, and alterations in blood flow were followed for 7 days. In the unstripped skin, D caused after 20 min exposure within 3 days a faint but defined erythema and increase in blood flow, and within 7 days a brownish hue. Irritation was suppressed by stripping after 20 min exposure. After 3 h contact, irrespective of stripping, much stronger irritation and staining developed. BD caused no staining after 20 min of exposure and little if any erythema. After 3 h contact, it caused only minimal staining and markedly less irritation than equimolar D.

UI	MeSH Term	Description	Entries
D011565	Psoriasis	A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004890	Erythema	Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	Erythemas
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000873	Anthracenes	A group of compounds with three aromatic rings joined in linear arrangement.
D000875	Anthralin	An anthracene derivative that disrupts function and structure of MITOCHONDRIA and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.	1,8-Dihydroxy-9-anthrone,Dithranol,1,8,9-Anthracenetriol,1,8-Dihydroxy-9(10H)-anthracenone,Anthraforte,Anthranol,Cignolin,Cygnoline,Dihydroxyanthranol,Dithrocream,Ditranol FNA,Lasan,Micanol,Psoradrate,Psoricrème,1,8 Dihydroxy 9 anthrone,FNA, Ditranol
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D013194	Staining and Labeling	The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.	Histological Labeling,Staining,Histological Labelings,Labeling and Staining,Labeling, Histological,Labelings, Histological,Stainings
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor