A short term anthralin application schedule was used at home in 42 patients with severe psoriasis. In another group of 21 patients treated at our day care center, UV-B irradiation was added when the surplus of anthralin had been washed off. Good healing results within 3-8 weeks were noted in most patients. To prevent relapses 31 patients continued the anthralin treatment once or twice a week after healing. In 15 cases this was combined with UV irradiation. One patient relapsed after a severe infection, but 16 others were observed for 6-9 months and 14 for 3-5 months without relapses. Irritation of non-affected skin is common especially at the beginning of the treatment and some staining of clothes and linen can occur. With proper information about this, the treatment is well accepted by the patient who generally finds it reasonably simple without the need of special protective dressings.