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We have generated measles virus-specific T cell clones from a patient with multiple sclerosis who has been described previously as a strong responder to measles virus. T cell clones were screened on the basis of their capacity to proliferate to measles virus. The cell surface phenotype of each clone was OKT3+, OKT4+, OKT8-. The majority of these clones (11 of 14) were cytotoxic for their autologous measles virus-infected lymphoblastoid B cell target. This cytotoxicity was specific for measles virus inasmuch as these T cell clones could not lyse influenza or mumps virus-infected B cell targets. By using a panel of HLA-defined measles virus-infected B cell lines, these clones were shown to recognize measles virus in the context of HLA class II determinants. A monoclonal antibody that recognizes HLA class II monomorphic determinants (L243), but not a monoclonal antibody that recognizes HLA class I antigens (W6/32), inhibited the lysis of the autologous measles virus-infected B cell target by these T cell clones. These results demonstrate that these cytotoxic T cell clones specific for measles virus are HLA class II restricted.
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J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
January 1988,
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S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
April 1988,
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S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
April 1989,
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S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
July 1984,
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S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
January 1988,
International archives of allergy and applied immunology,
S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
April 1989,
Cellular immunology,
S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
May 1993,
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S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
June 1982,
Nature,
S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
September 2001,
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S Jacobson, and
J R Richert, and
W E Biddison, and
A Satinsky, and
R J Hartzman, and
H F McFarland
May 1988,
The Journal of experimental medicine,
