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The composition of pepsin-solubilized glomerular basement membrane (GBM) collagen was studied in kidneys from patients with congenital nephrotic syndrome of the Finnish type (CNF). The 3-hydroxyproline content in the GBM collagen in CNF was only about one half of that noted in the controls. The alanine content was slightly higher in CNF, but no differences were found in the contents of the other amino acids or carbohydrates. Analysis of the GBM collagen by sodium dodecyl sulphate polyacrylamide gel electrophoresis after reduction indicated a lower proportion of one of the major polypeptide chains in CNF than in the controls, while a higher proportion of one low molecular weight minor component was noted. The activities of the five intracellular enzymes of collagen biosynthesis, including prolyl 3-hydroxylase, were not significancy altered in the CNF kidney cortex samples when compared with the controls.
K Tryggvason, and
J Risteli, and
K I Kivirikko
January 1983,
Nephron,
K Tryggvason, and
J Risteli, and
K I Kivirikko
June 1977,
European journal of clinical investigation,
K Tryggvason, and
J Risteli, and
K I Kivirikko
April 1977,
Scandinavian journal of clinical and laboratory investigation,
K Tryggvason, and
J Risteli, and
K I Kivirikko
March 1976,
Clinical nephrology,
K Tryggvason, and
J Risteli, and
K I Kivirikko
May 1994,
The Journal of the Association of Physicians of India,
K Tryggvason, and
J Risteli, and
K I Kivirikko
July 1995,
The Histochemical journal,
K Tryggvason, and
J Risteli, and
K I Kivirikko
January 1976,
Nephron,
K Tryggvason, and
J Risteli, and
K I Kivirikko
January 1982,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
K Tryggvason, and
J Risteli, and
K I Kivirikko
March 1985,
Acta pathologica japonica,
K Tryggvason, and
J Risteli, and
K I Kivirikko
April 2008,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
