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By using a murine monoclonal antibody produced against an IL 2-dependent human T cell line, we defined a T lineage-specific molecule, termed Ta1, that is expressed strongly on activated T lymphocytes of both the T4 and T8 subsets, as well as on T cell lines and clones, but only weakly on a fraction of resting T cells. SDS-PAGE analysis of immunoprecipitates from 125I-labeled, activated T cells demonstrates a single major band of apparent m.w. 105 KD under both reducing and nonreducing conditions. Unlike anti-IL 2 receptor antibodies, anti-Ta1 does not inhibit T cell proliferative responses to mitogen, antigen, or IL 2-containing medium. Moreover, anti-Ta1 has no effect on T cell-mediated cytotoxicity. Ta1 appears to be a novel human T cell-specific activation antigen that may serve as a useful marker of T cell activation in human disease.
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
March 1987,
Journal of immunology (Baltimore, Md. : 1950),
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
July 1986,
Journal of immunology (Baltimore, Md. : 1950),
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
October 1990,
Journal of leukocyte biology,
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
July 1990,
Tissue antigens,
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
June 1986,
Journal of immunology (Baltimore, Md. : 1950),
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
August 1984,
Journal of the National Cancer Institute,
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
March 1988,
British journal of cancer,
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
November 1980,
Somatic cell genetics,
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
October 1983,
Human immunology,
D A Fox, and
R E Hussey, and
K A Fitzgerald, and
O Acuto, and
C Poole, and
L Palley, and
J F Daley, and
S F Schlossman, and
E L Reinherz
March 1989,
Journal of immunology (Baltimore, Md. : 1950),
