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Recent studies using rabbit antisera to the separated HLA-DR alpha and beta subunits have suggested that alpha chain-specific, but not beta chain-specific, antisera inhibit T cell proliferative responses in primary and secondary human autologous mixed lymphocyte reaction (AMLR). In the present study, with the aid of sequential co-precipitation assays and Western blotting methods, a monoclonal rat alloantibody 1E4, specific for the beta chain of rat class II molecules carrying an Ia determinant Ba-2.7, was characterized to recognize a monomorphic determinant located on the beta chain of DR antigens. This antibody and a murine monoclonal antibody HU-4, also specific for the beta chain of DR antigens, strongly inhibited both primary and secondary AMLR through a mechanism distinct from an antibody-dependent cell-mediated cytotoxicity reaction. These results indicate that the inhibition of AMLR is not a unique feature of DR alpha-specific antibodies.
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
August 1984,
Tissue antigens,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
January 1982,
Immunogenetics,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
February 1988,
Transplantation,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
February 1984,
Immunology today,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
June 1972,
Transplantation proceedings,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
December 1987,
Journal of neuroimmunology,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
September 1971,
Clinical and experimental immunology,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
July 1985,
Arerugi = [Allergy],
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
September 1985,
FEBS letters,
M Kasahara, and
H Ikeda, and
K Ogasawara, and
N Ishikawa, and
T Okuyama, and
Y Fukasawa, and
H Kojima, and
H Kunikane, and
S Hawkin, and
T Ohhashi
August 1982,
European journal of immunology,
