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The effects of substance P on acetylcholinesterase activity have been examined. The neuropeptide produced a significant increase in the activity of the enzyme in rat cerebral cortex. Pretreatment of rats with either actinomycin-D or cycloheximide did not fully abolish the substance P-mediated stimulation of cerebral acetylcholinesterase. Substance P increased the enzyme activity in rat brain slices; moreover, substance P increased the activity of electric eel acetylcholinesterase in in vitro experiments. These observations indicate that substance P produces an induction of acetylcholinesterase in cerebral cortex of rats and in addition indicate that a direct action on the enzyme takes place.
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
January 1980,
Neuroscience,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
January 1983,
Ophthalmic research,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
May 1989,
The Journal of surgical research,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
September 1986,
Acta pharmacologica et toxicologica,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
May 1980,
The Journal of physiology,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
December 1986,
Journal of dental research,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
August 1982,
Acta physiologica Scandinavica,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
June 1983,
Naunyn-Schmiedeberg's archives of pharmacology,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
January 1984,
Biomedica biochimica acta,
R E Catalán, and
A M Martínez, and
M D Aragonés, and
B G Miguel, and
A Robles, and
J E Godoy
October 1982,
European journal of pharmacology,
